Finding Meaning Behind The Miles

This reflection was written by Amanda Melillo, PhD, a member of TargetCancer Foundation 2025’s Boston Marathon team

Running the Boston Marathon has been a longtime goal of mine. As someone who has completed many marathons over the years, I’ve always believed in finding meaning beyond the miles—whether that’s through fundraising, honoring loved ones, or supporting a cause that matters. This year, I had the opportunity to do all of that and more by running the 2025 Boston Marathon as a member of Team TCF.

TargetCancer Foundation supports research and awareness for rare cancers—an area that often doesn’t receive the attention it deserves. As a scientist and researcher myself, their mission resonates with me both personally and professionally. I understand how critical it is to invest in research, especially in areas that are underrepresented. On a more personal note, I’ve lost both of my parents—my mom to cancer and my dad to a rare disease—which made this experience all the more meaningful.

Members of Team TCF25 before a training run in Boston in early March

From the beginning, being part of Team TCF felt like joining a community. The team was welcoming and supportive, and I was inspired by the other runners, each of whom had their own connection to the cause. We met up during a practice weekend in Boston, and I was also able to train with a few team members in the DC area, which added a local sense of camaraderie. Those connections made the lead-up to race day feel more grounded and personal.

Race weekend itself was incredible. The energy in Boston during marathon weekend is something special, and Team TCF made sure we were supported every step of the way. From team gatherings to check-ins and encouragement, it was clear that this organization truly cares about its runners and its mission.

Marathon Monday was everything I hoped it would be. The course was challenging, but the crowds, the atmosphere, and the sense of purpose kept me going. Knowing I was running for a cause that aligns with both my personal story and my professional values added depth to every mile. It wasn’t just about finishing the race—it was about contributing to something bigger.

Crossing the finish line was a proud moment—not just for completing the marathon, but for being part of a team that’s working to make a real difference. Looking back, I’m grateful to have had the chance to run Boston this way. It checked a major box on my running bucket list, but more importantly, it reminded me why I keep showing up to the start line: not just for the love of running, but for the opportunity to support something meaningful.

Thank you to Team TCF for the opportunity and for everything you do to advance rare cancer research. I’m proud to have been part of this year’s team.